Minimal Hepatic Encephalopathy (MHE)
نویسندگان
چکیده
1. Episodic (precipitant-induced) encephalopathy, commonly seen in the hospital setting, where a superimposed event is a key factor. 2. Persistent (chronic) encephalopathy, seen with extensive portal–systemic shunts and after portocaval shunt surgery or placement of transjugular intrahepatic portosystemic shunt (TIPS). 3. Minimal (subclinical) encephalopathy reflects alterations in cognitive function in patients who clinically exhibit a normal mental state.
منابع مشابه
Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation
Hepatocellular carcinoma (HCC) patients were grouped according to the degree of encephalopathy, with healthy volunteers as controls. We investigated clinical presentation, protein and mRNA expression of 14 cytokines, and activation of six STAT proteins, the downstream signaling mediators. Levels of all 14 cytokines were significantly elevated in HCC patients with clinical hepatic encephalopathy...
متن کاملOlfactory deficits in patients affected by minimal hepatic encephalopathy: a pilot study.
Minimal hepatic encephalopathy (MHE) is the earliest stage of hepatic encephalopathy and is associated with changes in cognitive functions, in electrophysiological parameters, and in cerebral neurochemical/neurotransmitter homeostasis. MHE can be observed in patients with cirrhosis who have no clinical evidence of hepatic encephalopathy (HE). At present, no data are available on a possible olfa...
متن کاملMinimal hepatic encephalopathy in patients with decompensated liver cirrhosis.
Minimal hepatic encephalopathy (mHE) is characterized by some minimal unspecific alterations of cerebral functions that can only be detected by neuropsychological or neurophysiological diagnostic tests, which dysfunctions nevertheless interfere with the patient's daily living. Early recognition of these impairments may prevent the progression or delay the development of the disease to overt hep...
متن کاملPrevalence of minimal hepatic encephalopathy in cirrhotic patients.
Background. Minimal hepatic encephalopathy (MHE) has implications for health-related quality of life as well as for survival of cirrhotic patients, but a standardized diagnostic test is not available. Objective. To determine the prevalence of MHE among cirrhotic patients by using the psychometric hepatic encephalopathy score (PHES) system and the critical flicker frequency (CFF) test to diagnos...
متن کاملMinimal Hepatic Encephalopathy in Patients with Cirrhosis by Measuring Liver Stiffness and Hepatic Venous Pressure Gradient
BACKGROUND/AIM Transient elastography (TE) of liver and hepatic venous pressure gradient (HVPG) allows accurate prediction of cirrhosis and its complications in patients with chronic liver disease. There is no study on prediction of minimal hepatic encephalopathy (MHE) using TE and HVPG in patients with cirrhosis. PATIENTS AND METHODS Consecutive cirrhotic patients who never had an episode of...
متن کاملPrevalence of Helicobacter pylori Infection in Patients with Minimal Hepatic Encephalopathy.
BACKGROUND Ammonia is a critical factor in the pathogenesis of minimal hepatic encephalopathy (MHE). Most of the ammonia is from bacterial production in the intestinal tract. Non-absorbable antibiotics and non-absorbable disaccharides are therefore the therapy of choice. A few studies have addressed the effect of ammonia produced by H. pylori in the pathogenesis of MHE. METHODS In this prospe...
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